{"id":109,"date":"2025-07-04T18:59:08","date_gmt":"2025-07-04T10:59:08","guid":{"rendered":"https:\/\/xueqingzhang-lab.com\/?page_id=109"},"modified":"2026-04-16T21:56:16","modified_gmt":"2026-04-16T13:56:16","slug":"%e6%88%90%e6%9e%9c%e5%8f%8a%e8%ae%ba%e6%96%87","status":"publish","type":"page","link":"https:\/\/xueqingzhang-lab.com\/en\/%e6%88%90%e6%9e%9c%e5%8f%8a%e8%ae%ba%e6%96%87\/","title":{"rendered":"Achievements and Publications"},"content":{"rendered":"
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Representative Academic Achievements and Publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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  1. Chenshuang Zhang, William Stewart, Yilong Teng, Bin Hu, Xiaoyang Xu,* and Xue-Qing Zhang<\/strong>*; mRNA-Based Vaccination Drives in Vivo Dendritic Cell Reprogramming and Selective Cytotoxic T Lymphocyte Modulation for Enhanced Antitumor Immunity. ACS Nano<\/em><\/strong>, <\/em>2025,19(44): 38267-38283<\/li>\n
  2. Yilong Teng,# Yuxuan Guo,# Zhixiang Liu, Maoping Tang, William Stewart, Xiaoyang Xu,* and Xue-Qing Zhang*<\/strong>; Computationally Aided Design of Ionizable Cholesteryl Lipids for Lipid Nanoparticles to Modulate Hepatic mRNA Accumulation, Journal of the American Chemical Society, <\/em><\/strong>2025; 147(42):38865-38878<\/li>\n
  3. Bin Hu , William Stewart , Qijing Chen , Chenshuang Zhang , Zhixiang Liu , Xiaoyang Xu, Xue-Qing Zhang<\/strong>; Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA, Nature Communications<\/em><\/strong>, 2025; 16(1): 8120<\/li>\n
  4. Jia Huang; Xin Bai; William Stewart; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Budesonide-incorporated inhalable lipid nanoparticles for antiTSLP nanobody mRNA delivery to treat steroid-resistant asthma, Nature Communications<\/em><\/strong>, 2025; 16(1):6013.\uff08Co-corresponding Author\uff09<\/li>\n
  5. William Stewart , Bin Hu, Fengqiao Li, Jia Huang, Zhixiang Liu, Chenshuang Zhang, Maoping Tang, Xue-Qing Zhang<\/strong>*, Xiaoyang Xu; A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles. Journal of Controlled Release<\/em><\/strong><\/li>\n
  6. Chenshuang Zhang; Yilong Teng; Xin Bai; Maoping Tang; William Stewart; Jake Jinkun Chen; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy, ACS Nano<\/em><\/strong>, 2024;18(4):3260-3275. 2024;18(50):34375-34390.\uff08Co-corresponding Author\uff09<\/li>\n
  7. Kofi Oti Boakye-Yiadom, Qijing Chen, Yilong Teng, Chenshuang Zhang, Bin Hu, Xue-Qing Zhang<\/strong>; Injectable Gelled Multiple Emulsion for Glucose-Responsive Insulin Delivery, Advanced Healthcare Materials<\/em><\/strong>, 2024, 13(26): e2304195.\uff08Co-corresponding Author\uff09<\/li>\n
  8. Yingying Zeng; Xin Bai; Guiping Zhu; Mengchan Zhu; Wenjun Peng; Juan Song; Hui Cai; Ling Ye; Cuicui Chen; Yuanlin Song; Meiling Jin; Xue-Qing Zhang<\/strong>; Jian Wang; m6A-mediated HDAC9 upregulation promotes particulate matter-induced airway inflammation via epigenetic control of DUSP9-MAPK axis and acts as an inhaled nanotherapeutic target, Journal of Hazardous Materials<\/em><\/strong>, 2024;477:135093.\uff08Co-corresponding Author\uff09<\/li>\n
  9. Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu & Xue-Qing Zhang<\/strong>; Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy, Nature Communications<\/em><\/strong>. 2024, 15(1):6844.(ESI <\/strong>Highly Cited Paper<\/strong>)\uff08Co-corresponding Author\uff09<\/li>\n
  10. Bin Wang; Maoping Tang; Qijing Chen; William Ho; Yilong Teng; Xiaojian Xiong; Zhitong Jia; Xiuling Li; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion, ACS Nano<\/em><\/strong>, 2024;18(24):15499-15516.\uff08Co-corresponding Author\uff09<\/li>\n
  11. Mingzhu Gao; Yan Li; William Ho; Chen Chen; Qijing Chen; Fengshi Li; Maoping Tang; Qiuyue Fan; Jieqing Wan; Weifeng Yu; Xiaoyang Xu; Peiying Li; Xue-Qing Zhang<\/strong>; Targeted mRNA Nanoparticles Ameliorate Blood\u2013Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization, ACS Nano<\/em><\/strong>, 2024;18(4):3260-3275.\uff08Co-corresponding Author\uff09<\/li>\n
  12. Mingzhu Gao; Maoping Tang; William Ho; Yilong Teng; Qijing Chen; Lei Bu; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis, ACS Nano<\/em><\/strong>, 2023, 17(18):17721-17739.\uff08Co-corresponding Author\uff09<\/li>\n
  13. Chenshuang Zhang; Yilong Teng; Fengqiao Li; William Ho; Xin Bai; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells, ACS Nano<\/em><\/strong>, 2023, 17(15):14852-14870.\uff08Co-corresponding Author\uff09<\/li>\n
  14. Fengqiao Li#; Xue-Qing Zhang<\/strong>#*; William Ho; Maoping Tang; Zhongyu Li; Lei Bu; Xiaoyang Xu*; mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy, Nature Communications<\/em><\/strong>. 2023, 14(1):4223. (ESI <\/strong>Highly Cited Paper<\/strong>)\uff08Co-first author and co-corresponding author\uff09<\/li>\n
  15. Guolin Zhao; William Ho; Jinxian Chu; Xiaojian Xiong; Bin Hu; Kofi Oti Boakye-Yiadom; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer, ACS Applied Materials & Interfaces<\/em><\/strong>. 2023, 15 (26), 31273-31284.\uff08Co-corresponding Author\uff09<\/li>\n
  16. Shuo Xu#; Bin Hu#; Ting Dong#; Bo-Yan Chen; Xiao-Jian Xiong; Lin-Juan Du; Yu-Lin Li; Yan-Lin Chen; Guo-Cai Tian; Xue-Bing Bai; Ting Liu; Lu-Jun Zhou; Wu-Chang Zhang; Yan Liu; Qin-Feng Ding; Xue-Qing Zhang<\/strong>*; Sheng-Zhong Duan*; Alleviate Periodontitis and Its Comorbidity Hypertension using a Nanoparticle-Embedded Functional Hydrogel System, Advanced Healthcare Materials<\/em><\/strong>. 2023, 12 (20), e2203337.\uff08Co-corresponding Author\uff09<\/li>\n
  17. Xin Bai; Guolin Zhao; Qijing Chen; Zhongyu Li; Mingzhu Gao; William Ho; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge, Science Advances<\/em><\/strong>, 2022, 8(25): eabn7162. (ESI <\/strong>Highly Cited Paper<\/strong>)\uff08Co-corresponding Author\uff09<\/li>\n
  18. Zhongyu Li#; Xue-Qing Zhang<\/strong>#*; William Ho; Fengqiao Li; Mingzhu Gao; Xin Bai; Xiaoyang Xu*; Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines, ACS Nano<\/em><\/strong>, 2022, 16(11): 18936-18950.\uff08Co-first author and co-corresponding author\uff09<\/li>\n
  19. Zhongyu Li#; Xue-Qing Zhang<\/strong>#*; William Ho; Xin Bai; Dabbu Kumar Jaijyan; Fengqiao Li; Ranjeet Kumar; Afsal Kolloli; Selvakumar Subbian; Hua Zhu; Xiaoyang Xu*; Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure gene delivery platform explored for lyophilizable DNA and mRNA COVID-19 vaccines, Advanced Functional Materials<\/em><\/strong>, 2022, 32(40): 2204462. \uff08Co-first author and co-corresponding author\uff09<\/li>\n
  20. (9) Ziwei Yuan; Bin Wang; Yilong Teng; William Ho; Bin Hu; Kofi Oti Boakye-Yiadom; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Rational design of engineered H-ferritin nanoparticles for siRNA delivery across an in vitro BBB model, Nanoscale<\/em><\/strong>, 2022, 14(17): 6449-6464. \uff08Co-corresponding Author\uff09<\/li>\n
  21. (10) Bin Wang; Maoping Tang; Ziwei Yuan; Zhongyu Li; Bin Hu; Xin Bai; Jinxian Chu; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy, Bioactive materials<\/em><\/strong>, 2022, 16: 232-248. \uff08Co-corresponding Author\uff09<\/li>\n
  22. (11) Wei Yu#; Bin Hu#; Kofi Oti Boakye-Yiadom; William Ho; Qijing Chen; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment, Biomaterials<\/em><\/strong> Science, 2021, 9(22): 7603-7616. \uff08Co-corresponding Author\uff09<\/li>\n
  23. Bin Hu; Mingzhu Gao; Kofi Oti Boakye-Yiadom; William Ho; Wei Yu; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing, Bioactive materials<\/em><\/strong>, 2021, 6(12): 4592-4606. (ESI <\/strong>Highly Cited Paper<\/strong>)\uff08Co-corresponding Author\uff09<\/li>\n
  24. William Ho#; Mingzhu Gao#; Fengqiao Li; Zhongyu Li; Xue-Qing Zhang<\/strong>*; Xiaoyang Xu*; Next\u2010generation vaccines: nanoparticle\u2010mediated DNA and mRNA delivery, Advanced Healthcare Materials<\/em><\/strong>, 2021, 10(8): 2001812. (ESI <\/strong>Highly Cited Paper<\/strong>\uff09\uff08Co-corresponding Author\uff09<\/li>\n
  25. Xue Tian#; He Zhu#; Shibin Du; Xue-Qing Zhang<\/strong>; Fuqing Lin; Fengtao Ji; Yung-Hao Tsou; Zhongyu Li; Yi Feng; Kathryn Ticehurst; Stephen Hannaford; Xiaoyang Xu; Yuan-Xiang Tao*; Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain, The Journal of Pain<\/em><\/strong>, 2021, 22(2): 180-195.\uff08Co-corresponding Author\uff09<\/li>\n
  26. Zhongyu Li; William Ho; Xin Bai; Fengqiao Li; Yen-jui Chen; Xue-Qing Zhang<\/strong>*; Xiaoyang Xu*; Nanoparticle depots for controlled and sustained gene delivery, Journal of Controlled Release<\/em>,<\/strong> 2020, 322: 622-631. \uff08Co-corresponding Author\uff09<\/li>\n
  27. Bin Hu#; Kofi Oti Boakye-Yiadom#; Wei Yu; Zi-Wei Yuan; William Ho; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Nanomedicine approaches for advanced diagnosis and treatment of atherosclerosis and related ischemic diseases, Advanced Healthcare Materials<\/em><\/strong>, 2020, 9(16): 2000336. \uff08Co-corresponding Author\uff09<\/li>\n
  28. Qijing Chen#; Mingzhu Gao#; Zhongyu Li; Yue Xiao; Xin Bai; Kofi Oti Boakye-Yiadom; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy, Journal of Controlled Release<\/em><\/strong>, 2020, 323: 179-190. \uff08Co-corresponding Author\uff09<\/li>\n
  29. Zhize Yuan#; Yung-Hao Tsou#; Xue-Qing Zhang<\/strong>#; Shixing Huang; Yang Yang; Mingzhu Gao; William Ho; Qiang Zhao*; Xiaofeng Ye*; Xiaoyang Xu*; Injectable citrate-based hydrogel as an angiogenic biomaterial improves cardiac repair after myocardial infarction, ACS applied materials & interfaces<\/em><\/strong>, 2019, 11(42): 38429-38439. \uff08Co-first\uff09<\/li>\n
  30. Yung-Hao Tsou#; Bin Wang#; William Ho; Bin Hu; Pei Tang; Sydney Sweet; Xue-Qing Zhang<\/strong>*; Xiaoyang Xu*; Nanotechnology\u2010mediated drug delivery for the treatment of obesity and its related comorbidities, Advanced Healthcare Materials<\/em><\/strong>, 2019, 8(12): 1801184.\uff08Co-corresponding Author\uff09<\/li>\n
  31. Yung-Hao Tsou#; Xue-Qing Zhang<\/strong>#*; Xin Bai; He Zhu; Zhongyu Li; Yanlan Liu; Jinjun Shi; Xiaoyang Xu*; Dopant\u2010free hydrogels with intrinsic photoluminescence and biodegradable properties, Advanced Functional Materials<\/em><\/strong>, 2018, 28(34): 1802607. \uff08Co-first author and co-corresponding author\uff09<\/li>\n
  32. Xin Bai#; Mingzhu Gao#; Sahla Syed; Jerry Zhuang; Xiaoyang Xu; Xue-Qing Zhang<\/strong>; Bioactive hydrogels for bone regeneration, Bioactive materials<\/em><\/strong>, 2018, 3(4): 401-417. (ESI <\/strong>Highly Cited Paper<\/strong>)<\/li>\n
  33. Yung-Hao Tsou#; Xue-Qing Zhang<\/strong>#*; He Zhu; Sahla Syed; Xiaoyang Xu*; Drug delivery to the brain across the blood\u2013brain barrier using nanomaterials, Small<\/em><\/strong>, 2017, 13(43): 1701921. \uff08Co-first author and co-corresponding author\uff09<\/li>\n
  34. \u67cf\u6b23; \u7ae0\u96ea\u6674; \u5438\u5165\u5f0f\u6838\u9178\u7eb3\u7c73\u9012\u9001\u8f7d\u4f53: \u6311\u6218\u4e0e\u5bf9\u7b56, \u5f20\u6c5f\u79d1\u6280\u8bc4\u8bba, 2023, 3: 44-47.<\/li>\n
  35. \u738b\u658c; \u7ae0\u96ea\u6674; \u8111\u9776\u5411\u9012\u9001\u7b56\u7565\u7684\u6311\u6218\u548c\u673a\u9047, \u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u5b66\u62a5, 2021, 55(S1): 62-64.\uff08\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u5efa\u6821125\u5468\u5e74Science\u4e13\u520a\u2014\u2014125\u4e2a\u91cd\u8981\u7684\u79d1\u5b66\u524d\u6cbf\u95ee \u9898\u7efc\u8ff0\u9080\u7a3f\uff09<\/li>\n<\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

    \u4ee3\u8868\u6027\u5b66\u672f\u6210\u679c\u53ca\u8bba\u6587 Chenshuang Zhang, William Stewart, Yilong Te […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-109","page","type-page","status-publish","hentry"],"yoast_head":"\n\u6210\u679c\u53ca\u8bba\u6587 - xueqingzhang-lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xueqingzhang-lab.com\/en\/\u6210\u679c\u53ca\u8bba\u6587\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u6210\u679c\u53ca\u8bba\u6587 - xueqingzhang-lab\" \/>\n<meta property=\"og:description\" content=\"\u4ee3\u8868\u6027\u5b66\u672f\u6210\u679c\u53ca\u8bba\u6587 Chenshuang Zhang, William Stewart, Yilong Te […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/xueqingzhang-lab.com\/en\/\u6210\u679c\u53ca\u8bba\u6587\/\" \/>\n<meta property=\"og:site_name\" content=\"xueqingzhang-lab\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-16T13:56:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/xueqingzhang-lab.com\/%e6%88%90%e6%9e%9c%e5%8f%8a%e8%ae%ba%e6%96%87\/\",\"url\":\"https:\/\/xueqingzhang-lab.com\/%e6%88%90%e6%9e%9c%e5%8f%8a%e8%ae%ba%e6%96%87\/\",\"name\":\"\u6210\u679c\u53ca\u8bba\u6587 - 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