成果及论文

代表性学术成果及论文

  1. Chenshuang Zhang, William Stewart, Yilong Teng, Bin Hu, Xiaoyang Xu,* and Xue-Qing Zhang*; mRNA-Based Vaccination Drives in Vivo Dendritic Cell Reprogramming and Selective Cytotoxic T Lymphocyte Modulation for Enhanced Antitumor Immunity. ACS Nano, 2025,19(44): 38267-38283
  2. Yilong Teng,# Yuxuan Guo,# Zhixiang Liu, Maoping Tang, William Stewart, Xiaoyang Xu,* and Xue-Qing Zhang*; Computationally Aided Design of Ionizable Cholesteryl Lipids for Lipid Nanoparticles to Modulate Hepatic mRNA Accumulation, Journal of the American Chemical Society, 2025; 147(42):38865-38878
  3. Bin Hu , William Stewart , Qijing Chen , Chenshuang Zhang , Zhixiang Liu , Xiaoyang Xu, Xue-Qing Zhang; Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA, Nature Communications, 2025; 16(1): 8120
  4. Jia Huang; Xin Bai; William Stewart; Xiaoyang Xu; Xue-Qing Zhang; Budesonide-incorporated inhalable lipid nanoparticles for antiTSLP nanobody mRNA delivery to treat steroid-resistant asthma, Nature Communications, 2025; 16(1):6013.（共同通讯）
  5. William Stewart , Bin Hu, Fengqiao Li, Jia Huang, Zhixiang Liu, Chenshuang Zhang, Maoping Tang, Xue-Qing Zhang*, Xiaoyang Xu; A combinatorial siRNA and mRNA approach for obesity treatment using targeting lipid nanoparticles. Journal of Controlled Release
  6. Chenshuang Zhang; Yilong Teng; Xin Bai; Maoping Tang; William Stewart; Jake Jinkun Chen; Xiaoyang Xu; Xue-Qing Zhang; Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy, ACS Nano, 2024;18(4):3260-3275. 2024;18(50):34375-34390.（共同通讯）
  7. Kofi Oti Boakye-Yiadom, Qijing Chen, Yilong Teng, Chenshuang Zhang, Bin Hu, Xue-Qing Zhang; Injectable Gelled Multiple Emulsion for Glucose-Responsive Insulin Delivery, Advanced Healthcare Materials, 2024, 13(26): e2304195.（共同通讯）
  8. Yingying Zeng; Xin Bai; Guiping Zhu; Mengchan Zhu; Wenjun Peng; Juan Song; Hui Cai; Ling Ye; Cuicui Chen; Yuanlin Song; Meiling Jin; Xue-Qing Zhang; Jian Wang; m6A-mediated HDAC9 upregulation promotes particulate matter-induced airway inflammation via epigenetic control of DUSP9-MAPK axis and acts as an inhaled nanotherapeutic target, Journal of Hazardous Materials, 2024;477:135093.（共同通讯）
  9. Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu & Xue-Qing Zhang; Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy, Nature Communications. 2024, 15(1):6844.(ESI 高被引论文)（共同通讯）
  10. Bin Wang; Maoping Tang; Qijing Chen; William Ho; Yilong Teng; Xiaojian Xiong; Zhitong Jia; Xiuling Li; Xiaoyang Xu; Xue-Qing Zhang; Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion, ACS Nano, 2024;18(24):15499-15516.（共同通讯）
  11. Mingzhu Gao; Yan Li; William Ho; Chen Chen; Qijing Chen; Fengshi Li; Maoping Tang; Qiuyue Fan; Jieqing Wan; Weifeng Yu; Xiaoyang Xu; Peiying Li; Xue-Qing Zhang; Targeted mRNA Nanoparticles Ameliorate Blood–Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization, ACS Nano, 2024;18(4):3260-3275.（共同通讯）
  12. Mingzhu Gao; Maoping Tang; William Ho; Yilong Teng; Qijing Chen; Lei Bu; Xiaoyang Xu; Xue-Qing Zhang; Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis, ACS Nano, 2023, 17(18):17721-17739.（共同通讯）
  13. Chenshuang Zhang; Yilong Teng; Fengqiao Li; William Ho; Xin Bai; Xiaoyang Xu; Xue-Qing Zhang; Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells, ACS Nano, 2023, 17(15):14852-14870.（共同通讯）
  14. Fengqiao Li#; Xue-Qing Zhang#*; William Ho; Maoping Tang; Zhongyu Li; Lei Bu; Xiaoyang Xu*; mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy, Nature Communications. 2023, 14(1):4223. (ESI 高被引论文)（共同第一和通讯）
  15. Guolin Zhao; William Ho; Jinxian Chu; Xiaojian Xiong; Bin Hu; Kofi Oti Boakye-Yiadom; Xiaoyang Xu; Xue-Qing Zhang; Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer, ACS Applied Materials & Interfaces. 2023, 15 (26), 31273-31284.（共同通讯）
  16. Shuo Xu#; Bin Hu#; Ting Dong#; Bo-Yan Chen; Xiao-Jian Xiong; Lin-Juan Du; Yu-Lin Li; Yan-Lin Chen; Guo-Cai Tian; Xue-Bing Bai; Ting Liu; Lu-Jun Zhou; Wu-Chang Zhang; Yan Liu; Qin-Feng Ding; Xue-Qing Zhang*; Sheng-Zhong Duan*; Alleviate Periodontitis and Its Comorbidity Hypertension using a Nanoparticle-Embedded Functional Hydrogel System, Advanced Healthcare Materials. 2023, 12 (20), e2203337.（共同通讯）
  17. Xin Bai; Guolin Zhao; Qijing Chen; Zhongyu Li; Mingzhu Gao; William Ho; Xiaoyang Xu; Xue-Qing Zhang; Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge, Science Advances, 2022, 8(25): eabn7162. (ESI 高被引论文)（共同通讯）
  18. Zhongyu Li#; Xue-Qing Zhang#*; William Ho; Fengqiao Li; Mingzhu Gao; Xin Bai; Xiaoyang Xu*; Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines, ACS Nano, 2022, 16(11): 18936-18950.（共同第一和通讯）
  19. Zhongyu Li#; Xue-Qing Zhang#*; William Ho; Xin Bai; Dabbu Kumar Jaijyan; Fengqiao Li; Ranjeet Kumar; Afsal Kolloli; Selvakumar Subbian; Hua Zhu; Xiaoyang Xu*; Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure gene delivery platform explored for lyophilizable DNA and mRNA COVID-19 vaccines, Advanced Functional Materials, 2022, 32(40): 2204462. （共同第一和通讯）
  20. (9) Ziwei Yuan; Bin Wang; Yilong Teng; William Ho; Bin Hu; Kofi Oti Boakye-Yiadom; Xiaoyang Xu; Xue-Qing Zhang; Rational design of engineered H-ferritin nanoparticles for siRNA delivery across an in vitro BBB model, Nanoscale, 2022, 14(17): 6449-6464. （共同通讯）
  21. (10) Bin Wang; Maoping Tang; Ziwei Yuan; Zhongyu Li; Bin Hu; Xin Bai; Jinxian Chu; Xiaoyang Xu; Xue-Qing Zhang; Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy, Bioactive materials, 2022, 16: 232-248. （共同通讯）
  22. (11) Wei Yu#; Bin Hu#; Kofi Oti Boakye-Yiadom; William Ho; Qijing Chen; Xiaoyang Xu; Xue-Qing Zhang; Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment, Biomaterials Science, 2021, 9(22): 7603-7616. （共同通讯）
  23. Bin Hu; Mingzhu Gao; Kofi Oti Boakye-Yiadom; William Ho; Wei Yu; Xiaoyang Xu; Xue-Qing Zhang; An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing, Bioactive materials, 2021, 6(12): 4592-4606. (ESI 高被引论文)（共同通讯）
  24. William Ho#; Mingzhu Gao#; Fengqiao Li; Zhongyu Li; Xue-Qing Zhang*; Xiaoyang Xu*; Next‐generation vaccines: nanoparticle‐mediated DNA and mRNA delivery, Advanced Healthcare Materials, 2021, 10(8): 2001812. (ESI 高被引论文) （共同通讯）
  25. Xue Tian#; He Zhu#; Shibin Du; Xue-Qing Zhang; Fuqing Lin; Fengtao Ji; Yung-Hao Tsou; Zhongyu Li; Yi Feng; Kathryn Ticehurst; Stephen Hannaford; Xiaoyang Xu; Yuan-Xiang Tao*; Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain, The Journal of Pain, 2021, 22(2): 180-195.（共同通讯）
  26. Zhongyu Li; William Ho; Xin Bai; Fengqiao Li; Yen-jui Chen; Xue-Qing Zhang*; Xiaoyang Xu*; Nanoparticle depots for controlled and sustained gene delivery, Journal of Controlled Release, 2020, 322: 622-631. （共同通讯）
  27. Bin Hu#; Kofi Oti Boakye-Yiadom#; Wei Yu; Zi-Wei Yuan; William Ho; Xiaoyang Xu; Xue-Qing Zhang; Nanomedicine approaches for advanced diagnosis and treatment of atherosclerosis and related ischemic diseases, Advanced Healthcare Materials, 2020, 9(16): 2000336. （共同通讯）
  28. Qijing Chen#; Mingzhu Gao#; Zhongyu Li; Yue Xiao; Xin Bai; Kofi Oti Boakye-Yiadom; Xiaoyang Xu; Xue-Qing Zhang; Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy, Journal of Controlled Release, 2020, 323: 179-190. （共同通讯）
  29. Zhize Yuan#; Yung-Hao Tsou#; Xue-Qing Zhang#; Shixing Huang; Yang Yang; Mingzhu Gao; William Ho; Qiang Zhao*; Xiaofeng Ye*; Xiaoyang Xu*; Injectable citrate-based hydrogel as an angiogenic biomaterial improves cardiac repair after myocardial infarction, ACS applied materials & interfaces, 2019, 11(42): 38429-38439. （共同第一）
  30. Yung-Hao Tsou#; Bin Wang#; William Ho; Bin Hu; Pei Tang; Sydney Sweet; Xue-Qing Zhang*; Xiaoyang Xu*; Nanotechnology‐mediated drug delivery for the treatment of obesity and its related comorbidities, Advanced Healthcare Materials, 2019, 8(12): 1801184. （共同通讯）
  31. Yung-Hao Tsou#; Xue-Qing Zhang#*; Xin Bai; He Zhu; Zhongyu Li; Yanlan Liu; Jinjun Shi; Xiaoyang Xu*; Dopant‐free hydrogels with intrinsic photoluminescence and biodegradable properties, Advanced Functional Materials, 2018, 28(34): 1802607. （共同第一和通讯）
  32. Xin Bai#; Mingzhu Gao#; Sahla Syed; Jerry Zhuang; Xiaoyang Xu; Xue-Qing Zhang; Bioactive hydrogels for bone regeneration, Bioactive materials, 2018, 3(4): 401-417. (ESI 高被引论文)
  33. Yung-Hao Tsou#; Xue-Qing Zhang#*; He Zhu; Sahla Syed; Xiaoyang Xu*; Drug delivery to the brain across the blood–brain barrier using nanomaterials, Small, 2017, 13(43): 1701921. （共同第一和通讯）
  34. 柏欣; 章雪晴; 吸入式核酸纳米递送载体: 挑战与对策, 张江科技评论, 2023, 3: 44-47.
  35. 王斌; 章雪晴; 脑靶向递送策略的挑战和机遇, 上海交通大学学报, 2021, 55(S1): 62-64.（上海交通大学建校125周年Science专刊——125个重要的科学前沿问 题综述邀稿）